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BRI ON CHIP
Kidney stone disease is an illness caused by our affluent life style - with increasingsocio-economic
consequences. Currently at least 5 % of the population are affected. In emerging
countries an increasing number of stone patients are expected due to increasing prosperity.
Incorrect treatment leads to renewed stone formations with a probability of 10 %
in the first year, of 40 % after 5 years and of 75 % after 20 years.At present there
is no simple, low-cost and precise method to determine the risk of stone formation
in the market today. “BRI-on-Chip" is based on the established Bonn-Risk-Index, the
first test to determine the risk of urinary stone formation in a simple, quick and
convenient device. The feasibility of „BRI-on-Chip” has been demonstrated in
preliminary studies. A comprehensive “BRI-on-Chip” patent application has been registered.
With the "BRI-on-chip" in vitro diagnostic device the treatment regimes defined in
the guidelines of the European (EAU) and American (AUA) urological societies can
be readily applied and the therapy monitored.
The Bonn-Risk-Index (BRI) is designed to determine the crystallisation risk of calcium
oxalate which occurs in more than 75% of urinary stones as a main mineral phase.The
BRI will be determined by a native urine sample with an induced crystallisation test
in which several organic and non-organic urine components will be considered. The
physiochemical processes of nucleation, crystal growth and crystal aggregation which
belong to the formal genesis of urolithiasis, are being determined by the actual
interactions in the electrolyte system.
This methodical approach which imitates the processes of stone formation within the
body in a urine sample leads to the BRI being superior compared to the previously
performed individual analyses of less selected concentrations of lithogenic and inhibitory
The BRI concept allows in every treatment phase the classification of the patient
in a clear risk category. As an integral parameter which considers all the crystallisation
events affecting constituents of urine, it is clearly superior to the time- and cost-consuming
risk formulas from the concentration values of selected components.
Test your Bonn Risk Index (BRI)
NEW! BRI on CHIP
This product video shows how
the BRI-on-Chip works